GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs4660306 | 1 | rs10736426 | chr1:45984353 | CCDC163P | chr1:45960581-45965646:- | 0.47 | 6.48 | 1.23E-9 | Homocysteine levels |
| UCEC | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | TSFM | chr12:58176536-58191367:+ | -0.44 | -4.76 | 4.57E-6 | Multiple sclerosis |
| UCEC | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | TSFM | chr12:58176536-58191367:+ | -0.4 | -4.38 | 2.22E-5 | Multiple sclerosis |
| UCEC | cis | rs9815354 | 1 | rs10865914 | chr3:41919499 | ULK4 | chr3:41288091-42003660:- | -0.54 | -6.59 | 6.63E-10 | Diastolic blood pressure |
| UCEC | cis | rs703842 | 1 | rs10877012 | chr12:58162085 | TSFM | chr12:58176536-58191367:+ | -0.42 | -4.5 | 1.35E-5 | Multiple sclerosis |
| UCEC | cis | rs703842 | 1 | rs10877015 | chr12:58167788 | TSFM | chr12:58176536-58191367:+ | -0.41 | -4.37 | 2.31E-5 | Multiple sclerosis |
| UCEC | cis | rs703842 | 1 | rs10877019 | chr12:58172929 | TSFM | chr12:58176536-58191367:+ | 0.5 | 5.54 | 1.33E-7 | Multiple sclerosis |
| UCEC | cis | rs1577917 | 1 | rs10944161 | chr6:86630376 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs10944163 | chr6:86658693 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -5.8 | 3.64E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs10944169 | chr6:86683036 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs10944170 | chr6:86685469 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs12590640 | 1 | rs1106844 | chr14:36861613 | MBIP | chr14:36767764-36789882:- | 0.37 | 4.74 | 4.9E-6 | Malaria |
| UCEC | cis | rs12590640 | 1 | rs1106845 | chr14:36861356 | MBIP | chr14:36767764-36789882:- | 0.36 | 4.56 | 1.04E-5 | Malaria |
| UCEC | cis | rs11123170 | 1 | rs11123170 | chr2:113978940 | LOC654433 | chr2:113993107-114024579:+ | -0.75 | -8.55 | 1.22E-14 | Renal function-related traits (BUN) |
| UCEC | cis | rs111315781 | 1 | rs111315781 | chr2:201738724 | PPIL3 | chr2:201735680-201753999:- | -0.62 | -4.72 | 5.21E-6 | Triptolide cytotoxicity |